| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Darunavir Isavuconazole 996 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of darunavir and isavuconazole adverse effects |
Dose adjustment not established, monitor for increased DRV and / or antifungal adverse reactions |
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| Nevirapine Isavuconazole 584 | Green: Administer standard doses | Administer standard doses | Possible decreased Isavuconazole levels |
monitor for isravucanazole concentrations and anti fungal response |
|||
| Efavirenz Isavuconazole 397 | Green: Administer standard doses | Administer standard doses | Possible decreased Isavuconazole levels |
monitor for isravucanazole concentrations and anti fungal response |
|||
| Elvitegravir Isavuconazole 248 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | If coadministering monitor isavuconazole concentrations and assess virologic response. |
