| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Darunavir Valproic Acid 870 | Yellow: Adjust dosing | Adjust dosing to avoid decreased levels of valproic acid | Potential for decreased anticonvulsant effects |
Monitor anticonvulsant level and adjust accordingly |
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| Efavirenz Valproic acid 425 | Green: Administer standard doses | Administer standard doses | Efavirenz Cmin no significant change; Cmax no significant change; AUC no significant change; half-life: decreased 22% |
250 mg BID x 7 days | No significant change |
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| Raltegravir Valproic acid 325 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination |
If coadministering, monitor for raltegravir efficacy |
