Isoniazid

Generic
Isoniazid
Brand Name
Isoniazid
Synonym
INH
Import ID
17
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Interaction Color Code Clinical Bottom Line Clinical Effects Drug 1 effect Drug 2 dose Drug 2 effect Management
Dolutegravir INH 113 Red: Avoid combination Do not coadminister: Increased levels of izoniazid and reduced levels of dolutegravir

Potential for increased adverse effects of isoniazid (flu-like symptoms, nausea, vomiting, and fever)

AUC decreased 46%, Cmin decreased 74%

15 mg / kg + rifapentine 900 mg once weekly

INH AUC increased 67-92% in 2 / 4 subjects. Rifapentine no significant change.

Use alternative agents