| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Rilpivirine (IM) Erythromycin | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased rilpivirine concentrations |
Consider alternative agents. If coadministration is necessary, monitor for adverse effects |
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| Darunavir Erythromycin 1033 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of antibacterial adverse effects |
Use alternative agents |
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| Atazanavir Erythromycin 842 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Avoid combination, use alternative antibiotics |
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| Elvitegravir Erythromycin 280 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Use alternative agents |
