| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Tramadol | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Increased risk of tramadol adverse effects |
If coadministering, consider decreasing tramadol dose when coadministering. Titrate to clinical effect and monitor for sedation. |
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| Darunavir Tramadol 977 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased risk of tramadol adverse effects |
Clinical monitoring is recommended. Dose reduction may be needed |
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| Elvitegravir Tramadol 275 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased sedation |
Initiate tramadol at lowest dose. If initiating elvitegravir / cobicistat, tramadol may require a dose reduction - monitor for efficacy and adverse effects to titrate. |
