| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Oxycodone | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Increased risk of oxycodone adverse effects |
If coadministering, monitor therapeutic effects and adverse reactions (e.g. sedation, respiratory depression) |
|||
| Darunavir Oxycodone 976 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased risk of oxycodone adverse effects (e.g. respiratory depression) |
Clinical monitoring is recommended |
