| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Darunavir Tamsulosin 987 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased risk of tamsulosin adverse effects |
If coadministering, monitor for clinical toxicities |
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| Nevirapine Tamsulosin 630 | Orange: Minimal data to guide interaction | Adjust dosing to avoid decreased levels of tamsulosin | Decreased tamsulosin effects |
If coadministring, monitor for theraptutic effectiveness of tamsulosin after 2-4 weeks. Increase dose to 0.8mg daily for patients who fail to respond to 0.4 mg dose. |
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| Etravirine Tamsulosin 557 | Orange: Minimal data to guide interaction | Adjust dosing to avoid decreased levels of tamsulosin | Decreased tamsulosin effects |
If coadministring, monitor for theraptutic effectiveness of tamsulosin after 2-4 weeks. Increase dose to 0.8mg daily for patients who fail to respond to 0.4 mg dose. |
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| Elvitegravir Tamsulosin 227 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased tamulosin adverse effects |
Use alternate agents. If coadministering, use with caution and monitor for tamulosin related adverse effects |
