| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Darunavir Doxazosin 1004 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of doxazosin adverse effects |
If coadministering, initiate at lowest dose and titrate while monitoring for clinical response / adverse effects |
|||
| Elvitegravir Doxazosin 162 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of doxazosin | Potential for increased risk of doxazosin adverse effects |
Initiate low dose doxazosin and titrate dose according to efficacy and adverse effects. |
