Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 1 dose
600 mg BID x 2 days, then 600 mg daily x 1
Drug 1 effect
Not reported
Drug 2
Drug 2 dose
2.5 mg orally x 1 with food, administered 1 day after LEN
Drug 2 effect
AUC increased 308%; Cmax increased 116%. AUC for 1-hydroxy metabolite decreased 16%.
Clinical Effects
Potential for increased sedation
Management
If co-administering, monitor for excess sedation and adjust dose accordingly
Info Source
