Lenacapavir Tenofovir alafenamide

Sunlenca Product Label

Interaction Color Code
Clinical Bottom Line
Administer standard doses
Drug 1
Drug 1 dose
600 mg BID x 2 days, then 600 mg daily x 1
Drug 1 effect

Not reported

Drug 2 dose
25 mg x 1
Drug 2 effect

TAF AUC increased 32%; Cmax increased 24%. TFV AUC increased 47%; Cmax increased 23%

Mechanism
Inhibition of P-gp by lenacapavir
Clinical Effects

No clinically significant effect expected