DHHS Adult ARV Guidelines
Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 2
Mechanism
Inhibition of CYP3A4 by lenacapavir
Clinical Effects
Potential increased risk of quetiapine adverse effects (e.g. sedation, QT prolongation)
Management
Consider using alternative antipsychotics. If coadministering, consider quetiapine dose reduction and monitor for adverse effects.
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