Lenacapavir Midazolam

Sunlenca Product Label

Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 1 dose
600 mg BID x 2 days, then 600 mg daily x 1
Drug 1 effect

Not reported

Drug 2
Drug 2 dose
2.5 mg orally x 1, administered simultaneously with LEN
Drug 2 effect

AUC increased 259%; Cmax increased 94%. AUC for 1-hydroxy metabolite decreased 24%.

Clinical Effects

Potential for increased sedation

Management

If co-administering, monitor for excess sedation and adjust dose accordingly