DHHS Adult ARV Guidelines
Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 2
Mechanism
Inhibition of CYP3A4 by lenacapavir
Clinical Effects
Potential increased risk of avanafil adverse effects (e.g. hypotension)
Management
If coadministering, avanafil dose should not exceed 50 mg in 24 hours
Info Source
