Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 1 dose
Days 1-5 none; day 6 300 mg Q12H; day 7 400 mg Q12H; days 8-15 500 mg Q12H
Drug 2
Drug 2 dose
3 mg / kg Q8H
Drug 2 effect
Theophylline AUC decreased 43%; Cmax decreased 32%; Cmin decreased 57%; half-life: decreased 57%
Clinical Effects
Decreased theophylline effects
Management
Monitor and adjust theophylline as clinically indicated
Import ID
1103
