Ritonavir Alprazolam 1097

Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 1 dose
500 mg BID x 10 days
Drug 2
Drug 2 dose
1 mg x 1
Drug 2 effect

Alprazolam AUC no significant change; Cmax decreased 16%

Management

Avoid combination and use alternative agents

Alternative Agents
Lorazepam
Import ID
1097