Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 1 dose
200 mg BID
Drug 2
Drug 2 dose
1 mg x 1 dose
Drug 2 effect
Alprazolam clearance: decreased 59%; half-life: increased 122%
Clinical Effects
Increased alprazolam effects (eg, increased sedation, confusion, respiratory depression)
Management
Avoid combination and use alternative agents
Alternative Agents
Lorazepam
Import ID
1096
