Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of ethinyl estradiol
Drug 1
Drug 1 dose
500 mg Q12H
Drug 2 dose
50 mcg x 2 doses
Drug 2 effect
Ethinyl estradiol Cmax decreased 32%; AUC decreased 41%
Clinical Effects
Decreased oral contraceptive effectiveness
Management
Use alternative contraceptive method
Alternative Agents
Barrier devices; Condoms
Import ID
1084
