Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of methadone
Drug 1
Drug 1 dose
400 mg BID combined with 400 mg BID saquinavir
Drug 2
Drug 2 effect
S-methadone AUC decreased 25%; R-methadone AUC decreased 20%
Clinical Effects
Not clinically significant
Management
If coadministering monitor for signs and symptoms of methadone withdrawal. Some patients may require an increased methadone dose
Import ID
1052
