Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of methadone
Drug 1
Drug 1 dose
400 mg BID x 7 days
Drug 2
Drug 2 dose
90 mg daily x 2 years
Drug 2 effect
Methadone AUC decreased
Clinical Effects
Decreased methadone effects (eg, methadone withdrawal)
Management
If coadministering monitor for signs and symptoms of methadone withdrawal. Some patients may require an increased methadone dose
Import ID
1051
