Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of rifabutin
Drug 1
Drug 1 dose
300 mg on day 15; 400 mg on day 16; 500 mg on days 17-24
Drug 2
Drug 2 dose
150 mg daily x 24 days
Drug 2 effect
Rifabutin AUC increased 400%; Cmax increased 250%
Clinical Effects
Increased rifabutin effects (eg, uveitis)
Management
Decrease rifabutin to 150 mg every other day or 300 mg 3 times / week
Import ID
1043
