Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of clarithromycin
Drug 1
Drug 1 dose
200 mg TID
Drug 1 effect
AUC no significant change; Cmax increased 15%
Drug 2
Drug 2 dose
500 mg BID
Drug 2 effect
Clarithromycin AUC increased 77%; Cmax increased 31%; Cmin increased 182%
Clinical Effects
Increased clarithromycin effects
Management
Reduce clarithromycin dose by 50% in patients with CrCl 30-60 mL / min. Reduce clarithromycin dose by 75% in patients with CrCl <30 mL / min.
Import ID
1038
