Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of bosentan
Drug 1
Drug 1 effect
Not studied
Drug 2
Drug 2 effect
Not studied (may increase bosentan levels)
Clinical Effects
Possible increased bosentan effects
Management
Start low and titrate bosentan to effect. If patient has been on protease inhibitor (other than unboosted atazanavir) for more than 10 days, start bosentan at 62.5 mg daily or every other day. If patient is currently on bosentan and requires a PI (other than unboosted atazanavir), stop bosentan for at least 36 hours prior to initiating ART. Wait 10 days and then resume bosentan starting with 62.5 mg daily or every other day.
Import ID
1037
