Prezista label
Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 1 dose
600 mg with 100 mg ritonaivr BID
Drug 1 effect
Darunavir: No significant change; Ritonavir cmax decreased 44%, AUC decreased 49%, Cmin decreased 56%
Drug 2
Drug 2 dose
200 mg BID
Drug 2 effect
Cmax increase 43%, AUC increase 45%, Cmin increase 54%
Clinical Effects
Increased carbamazepine effects
Management
Monitor anticonvulsant level and adjust accordingly. Consider carbamazepine dose reduction by 25-50%. Monitor antiviral efficacy
Import ID
1029
