Darunavir Ketoconazole 999

Prezista label

Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 1 dose
400 mg with 100 mg ritonavir BID
Drug 2
Drug 2 dose
200 mg BID
Clinical Effects

Potential for increased darunavir and ketoconazole adverse effects

Management

Dose adjustment not established; if co-administration needed, ketoconazole dose should not exceed 200 mg daily

Import ID
999