Darunavir Phenytoin 962

Prezista label

Clinical Bottom Line
Minimal data to guide interaction: risks likely to outweigh benefits
Drug 1
Drug 2
Clinical Effects

Potential loss of antiviral efficacy, Potential for decreased phenytoin effects

Management

Avoid combination and use alternative agents. If coadministering, monitor and adjust phenytoin levels as indicated and monitor viral load.

Alternative Agents
Gabapentin, Lamotrigine, Tiagabine, Topiramate
Import ID
962