Prezista label
Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of ethinyl estradiol and norethindrone
Drug 1
Drug 1 dose
600 mg with 100 mg ritonavir BID
Drug 1 effect
No significant change
Drug 2 dose
35 mcg / 1.0 mg once daily
Drug 2 effect
Ethinyl estradiol: Cmax decrease 32%, AUC decrease 44%, Cmin decrease 62%; Norethindrone: Cmax decrease 10%, AUC decrease 14%, Cmin decrease 30%
Clinical Effects
Potential decreased ethinyl estradiol and norethindrone effects (e.g. contraceptive failure)
Management
Use alternative agents. If coadministering, back-up contraceptive methods are recommended.
Alternative Agents
Barrier devices; Condoms
Import ID
959
