Prezista label
Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of darunavir
Drug 1
Drug 1 dose
800 mg daily
Drug 1 effect
Darunavir Cmax decreased 8%; AUC decreased 24%; Cmin decreased 48%
Drug 2 dose
250 mg BID + 25 / 150 / 100 mg once daily
Drug 2 effect
Dasabuvir Cmax increase 10%, AUC decrease 6%, Cmin increase 10%; Ombitasvir Cmax and AUC decrease 14%, Cmin decrease 13%; Paritaprevir Cmin increase 54%, AUC increase 29%, Cmin increase 30%
Clinical Effects
Potential decreased anti-HCV and anti-HIV efficacy
Management
Use alternative agents
Import ID
958
