Prezista label
Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of darunavir
Drug 1
Drug 1 dose
800 mg with 100 mg ritonavir once daily
Drug 1 effect
Cmax decrease 21%, AUC increase 34%, Cmin decrease 46%
Drug 2 dose
250 mg BID + 25 / 150 / 100 mg once daily
Drug 2 effect
Dasabuvir Cmax decrease 25%, AUC decrease 28%, Cmin decrease 35%; Ombitasvir Cmax, AUC, and Cmin decrease 13%; Paritaprevir Cmax decrease 30%, AUC decrease 19%, Cmin increase 59%
Clinical Effects
Potential decreased anti-HCV and anti-HIV efficacy
Management
Use alternative agents
Import ID
957
