Prezista label
Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of darunavir
Drug 1
Drug 1 dose
600 mg BID with ritonavir 100 mg once daily in the evening
Drug 1 effect
Cmax decrease 13%, AUC decrease 20%, Cmin decrease 43%
Drug 2 dose
250 mg BID + 25 / 150 / 100 mg once daily
Drug 2 effect
Dasabuvir Cmax decrease 16%, AUC decrease 27%; Cmin decrease 46%; Ombitasvir Cmax decrease 24%, AUC and Cmin decrease 27%; Paritaprevir Cmax decrease 30%, AUC decrease 41%, Cmin decrease 17%
Clinical Effects
Potential decreased anti-HCV and anti-HIV efficacy
Management
Use alternative agents
Import ID
956
