Prezista label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of methadone
Drug 1
Drug 1 dose
600 mg with 100 mg ritonavir BID
Drug 1 effect
Not reported
Drug 2
Drug 2 dose
55-200 mg once daily (stable dose)
Drug 2 effect
R-methadone: Cmax decrease 24%, AUC decrease 16%, Cmin decrease 15%; S-methadone: Cmax decrease 44%, AUC decrease 36%, Cmin decrease 40%
Clinical Effects
May decrease methadone effects (e.g. withdrawal)
Management
If coadministering monitor for signs and symptoms of methadone withdrawal. Some patients may require an increased methadone dose
Import ID
896
