Prezista label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of rosuvastatin
Drug 1
Drug 1 dose
600 mg with 100 mg ritonavir BID
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
10 mg once daily
Drug 2 effect
Cmax increase 144%,AUC increase 48%
Clinical Effects
Increased risk of rosuvastatin adverse effects (e.g. myopathy, rhabdomyolysis); No change in lipid lowering ability within 35 day study period
Management
Consider using alternative agents. If coadministering, consider initiating low dose rosuvastatin 5 mg daily
Import ID
888
