Prezista label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of rifabutin
Drug 1
Drug 1 dose
600 mg with 100 mg ritonavir BID
Drug 1 effect
Darunavir Cmax increase 42%, AUC increase 57%, Cmin increase 75%; Ritonavir Cmax increase 68%, AUC increase 66%, Cmin increase 31%
Drug 2
Drug 2 dose
150 mg every other day
Drug 2 effect
Rifabutin: Cmax decrease 28%, AUC decrease 7%, Cmin increase 64%; 25-O-desacetylrifabutin: Cmax increase 377%, AUC increase 881%, Cmin increase 2610%
Clinical Effects
Increased darunavir and rifabutin effects. Note that lower rifabutin exposure has been reported in HIV- infected patients as compared to healthy study participants.
Management
Dose reduction of RFB by 75% of usual dose is recommended, such as rifabutin 150 mg every other day. Monitor for antimycobacterial activity and adverse events. Consider therapeutic drug monitoring.
Import ID
886
