Prezista label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of pravastatin
Drug 1
Drug 1 dose
600 mg with 100 mg ritonavir BID
Drug 1 effect
Not studied
Drug 2
Drug 2 dose
40 mg x 1
Drug 2 effect
Cmax increase 63%, AUC increase 81%
Clinical Effects
Increased risk of pravastatin adverse effects (e.g. myopathy, rhabdomyolysis)
Management
Use lowest possible starting dose, monitor for toxicity and titrate.
Import ID
885
