Darunavir MVC 884

Prezista label

Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of maraviroc
Drug 1
Drug 1 dose
600 mg with 100 mg ritonavir BID with etravirine 200 mg BID
Drug 1 effect

Not reported

Drug 2
Drug 2 dose
150 mg BID
Drug 2 effect

Cmax increase 77%, AUC increase 210%, Cmin increase 427%

Clinical Effects

Potential for increased maraviroc adverse effects

Management

Use maraviroc 150 mg BID when combined with darunavir / ritonavir

Import ID
884