Prezista label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of clarithromycin
Drug 1
Drug 1 dose
400 mg with 100 mg ritonavir BID
Drug 1 effect
Cmax decrease 17%, AUC decrease 13%, Cmin increase 1%
Drug 2
Drug 2 dose
500 mg BID
Drug 2 effect
Cmax increase 26%, AUC increased 57%, Cmin increase 174%
Clinical Effects
Increased risk of antibacterial adverse effects
Management
In patients with CrCl 30-60 mL / min, reduce dose of clarithromycin by 50%. In patients with CrCl <30 mL / min, reduce clarithromycin dose by 75%. Monitor for clarithromycin-related toxicities and / or consider alternative macrolide.
Alternative Agents
Azithromycin
Import ID
880
