Prezista label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of atorvastatin
Drug 1
Drug 1 dose
300 mg with 100 mg ritonavir BID
Drug 1 effect
Not reported
Drug 2
Drug 2 dose
40 mg once daily on days 1-4, then 10 mg once daily on days 4-7
Drug 2 effect
Cmax decrease 44%, AUC decrease 15%, Cmin increase 81% (10 mg daily with darunavir / ritonavir compared to atorvastatin 40 mg daily alone)
Clinical Effects
Increased risk of atorvastatin adverse effects (e.g. myopathy, rhabdomyolysis)
Management
Consider using alternative agents. If coadministering, consider low dose atorvastatin and doses < 20 mg. Monitor for myopathy
Import ID
871
