Prezista label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of buprenorphine / naloxone
Drug 1
Drug 1 dose
600 mg with 100 mg ritonavir BID
Drug 1 effect
Not studied
Drug 2
Drug 2 dose
8-16 / 2-4 mg
Drug 2 effect
Norbuprenorphine: Cmax increase 36%, AUC increase 46%, Cmin increase 71%
Clinical Effects
Potential for increased buprenorphine / naloxone effects
Management
If initiating buprenorphine / naloxone in patients taking DRV / r or DRV / c, carefully titrate dose to desired effect
Import ID
866
