Reyataz label
Interaction Color Code
Clinical Bottom Line
Administer standard doses
Drug 1
Drug 1 dose
Atazanavir / ritonavir 300 mg / 100mg daily given simultaenously for 10 days plus emtricitabine / tenofovir DF 200mg / 300mg daily
Drug 1 effect
Atazanavir AUC increased 27%, Cmin increased 63%
Drug 2
Drug 2 dose
90 / 400 mg
Drug 2 effect
Ledipasvir AUC(tau) increased 96%, Cmax increased 68%.
Clinical Effects
Potentially increased ledipasvir adverse effects. Potentially increased tenofovir disoproxil fumarate adverse effects if coadministered with protease inhibitor and ledipasvir.
Management
If coadministering, monitor for tenofovir disoproxil fumarate toxicity if used in the regimen.
Import ID
803
