Reyataz label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of hormonal contraception
Drug 1
Drug 1 dose
300 mg atazanavir daily with 100 mg ritonavir daily
Drug 2 effect
Ethinyl estradiol AUC decreased 19%, Cmax decreased 16%, Cmin decreased 37% 17-deacetyl norgestimate AUC increased 85%, Cmax increased 68%, Cmin increased 102%
Management
With ritonavir boosted atazanavir, use an oral contraceptive containing at least 35 mcg of ethinyl estradiol. Oral contraceptives containing progestins other than norethindrone or norgestimate have not been studied.
Alternative Agents
Non-hormonal contraceptives, barrier devices, condoms
Import ID
799
