Reyataz label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of atazanavir
Drug 1
Drug 1 dose
400 mg daily on days 1-20
Drug 1 effect
Atazanavir AUC decreased 74%, Cmax decreased 59%, Cmin decreased 93%, half-life: decreased 27%
Drug 2
Drug 2 dose
600 mg daily on days 7-20
Drug 2 effect
No significant change
Clinical Effects
Potential loss of antiretroviral efficacy
Management
In ART-naive patients standard dose efavirenz may be used with atazanavir 400 mg boosted with ritonavir 100 mg once daily. Do not coadminister efavirenz plus ritonavir-boosted atazanavir in ART-experienced patients. Do not coadminister efavirenz with unboosted atazanavir.
Import ID
790
