Reyataz label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of atazanavir
Drug 1
Drug 1 dose
400 mg daily on days 1-28
Drug 1 effect
Atazanavir AUC increased 241%, Cmax increased 124%, Cmin increased 671%, half-life: increased 79%
Drug 2
Drug 2 dose
600 mg daily with ritonavir 200 mg on days 15-28
Drug 2 effect
Not reported
Clinical Effects
Potential for increased atazanavir adverse effects
Management
In ART-naive patients standard dose efavirenz may be used with atazanavir 400 mg boosted with ritonavir 100 mg once daily. Do not coadminister efavirenz plus ritonavir-boosted atazanavir in ART-experienced patients. Do not coadminister efavirenz with unboosted atazanavir.
Import ID
789
