Reyataz label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of atazanavir
Drug 1
Drug 1 dose
400 mg daily on d 1-12
Drug 1 effect
Not reported
Drug 2
Drug 2 dose
40 mg x 1 on d 7 and 20
Drug 2 effect
Omeprazole AUC increased 45%, Cmax increased 24%
Clinical Effects
Increased omeprazole effects
Management
Do not coadminister PPIs with unboosted atazanavir. PPIs may be administered 12 hours before atazanavir when boosted with ritonavir or cobicistat, in treatment naive patients. Doses should not exceed the equivalent of omeprazole 20 mg daily. PPIs are not recommended for treatment experienced patients.
Alternative Agents
H2 receptor antagonists
Import ID
778
