Reyataz label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of atazanavir
Drug 1
Drug 1 dose
300 mg daily with ritonavir 100 mg daily on days 1-42
Drug 1 effect
Atazanavir Cmax decreased 28%, AUC decreased 25%, Cmin decreased 26%, Ritonavir Cmax decreased 28%, AUC decreased 25%, Cmin no significant change
Drug 2 dose
300 mg daily on days 15-42
Drug 2 effect
Not reported
Clinical Effects
Potential loss of antiretroviral efficacy with lower atazanavir concentrationss. Potential for increased tenofovir adverse effects
Management
Administer 300 mg atazanavir with 100 mg ritonavir when used as part of a tenofovir containing regimen. Do not coadminister TDF with unboosted atazanavir (400 mg).
Import ID
775
