Reyataz label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced atazanavir levels
Drug 1
Drug 2
Clinical Effects
Potential decreased antiviral effects of atazanavir
Management
Do not coadminister bosentan with unboosted atazanavir, For patients receiving atazanavir plus ritonavir for >10 days, start bosentan at 62.5mg daily or every other day based on individual tolerability, Discontinue bosentan at least 36 hours before starting atazanavir / ritonavir. At least 10 days after starting atazanavir / ritonavir, resume bosentan at 62.5mg daily or every other day based on individual tolerability.
Import ID
773
