Reyataz label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of rosuvastatin
Drug 1
Drug 1 dose
300 mg atazanavir daily with ritonavir 100 mg daily
Drug 2
Drug 2 dose
10 mg daily
Drug 2 effect
Rosuvastatin AUC increased 213%, Cmax increased 600%
Clinical Effects
Potential for increased rosuvastatin adverse effects (e.g. myopathy)
Management
Initiate lowest dose and titrate carefully. Do not exceed 10mg rosuvastatin daily.
Alternative Agents
Pravastatin, atorvastatin
Import ID
769
