Reyataz label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of rifabutin
Drug 1
Drug 1 dose
400 mg daily on days 1-14, 400 mg daily with ritonavir 100 mg daily on days 15-28
Drug 1 effect
Atazanavir AUC increased 191%, Cmax increased 81%
Drug 2
Drug 2 dose
150 mg daily on days 15-28
Drug 2 effect
Not reported
Clinical Effects
Potential increase in atazanavir adverse effects
Management
Use rifabutin 150 mg once daily or 300 mg three times a week. Monitor for antimycobacterial activity and consider therapeutic drug monitoring.
Import ID
767
