Reyataz label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of rifabutin
Drug 1
Drug 1 dose
600 mg daily on days 11-20
Drug 1 effect
Not reported
Drug 2
Drug 2 dose
300 mg daily on days 1-10, then 150 mg daily on days 11-20
Drug 2 effect
Rifabutin AUC increased 110%, Cmax increased 118%, Cmin increased 243%, 25-O-desacetylrifabutin AUC increased 2101%, Cmax increased 720%, Cmin increased 7460%
Clinical Effects
Increased rifabutin effects (eg, uveitis)
Management
Use rifabutin 150 mg once daily or 300 mg three times a week. Monitor for antimycobacterial activity and consider therapeutic drug monitoring.
Import ID
766
