Reyataz label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of hormonal contraception
Drug 1
Drug 1 dose
400 mg daily x 14 days
Drug 2 dose
1 tab daily (7 / 7 / 7)
Drug 2 effect
Norethindrone Cmax increased 67%, AUC increased 110%, Cmin increased 262%, Ethinyl estradiol AUC increased 48%, Cmax no significant change, Cmin increased 91%
Clinical Effects
Increased norethindrone and ethinyl estradiol effects
Management
For unboosted atazanavir, use an oral contraceptive that contains no more than 30 mcg of ethinyl estradiol or recommend an alternative contraceptive method. Oral contraceptives containing less than 25mcg of ethinyl estradiol or progestins other than norethindrone or norgestimate have not been studied.
Alternative Agents
Non hormonal contraceptive method, barrier devices, condoms
Import ID
761
