Reyataz label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of diltiazem
Drug 1
Drug 1 dose
400 mg daily on days 1-11
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
180 mg daily on days 7-11 and 19-23
Drug 2 effect
Diltiazem AUC increased 125%, Cmax increased 198%, Cmin decreased 59%
Clinical Effects
Potential for increased diltiazem effects (eg, hypotension, heart block)
Management
Reduce diltiazem dose by 50%. ECG monitoring is recommended.
Import ID
760
