Reyataz label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of clarithromycin
Drug 1
Drug 1 dose
400 mg daily on days 1-10
Drug 1 effect
Atazanavir AUC increased 28%, Cmax no significant change, Cmin increased 91%
Drug 2
Drug 2 dose
500 mg BID on days 7-11 and 18-21
Drug 2 effect
Clarithromycin AUC increased 94%, Cmax increased 50%, Cmin decreased 62%, 14-hydroxyclarithromycin AUC decreased 70%, Cmax decreased 72%, Cmin increased 164%
Clinical Effects
Potential for increased clarithromycin effects. (e.g. may cause QTc prolongation).
Management
Reduce clarithromycin dose by 50%
Alternative Agents
Azithromycin
Import ID
756
